Genetic variations associated with coronary artery disease and myocardial infarction in the Arab world: a systematic review and meta-analysis

Salma Younes, Zumin Shi, Hatem Zayed

Abstract


Coronary artery disease (CAD) and myocardial infarction (MI) have reached epidemic levels in the Arab world. The well-recognized familial clustering of CAD implies that genetics plays a key role in its development. Several CAD/MI genetic association studies have been conducted, but the outcomes have been inconsistent. In this study, we aimed to systematically review and quantitatively summarize the current evidence on genetic polymorphisms associated with CAD/MI risk in the Arab world. We systematically searched five literature databases (Science Direct, PubMed, Scopus, EMBASE, and Web of Science). We included all genetic polymorphisms with odds ratio (OR) > 1 that were significantly associated with CAD/MI risk among Arabs. Review Manager software v5.02 was used to conduct the meta-analysis. Publication bias was measured using Begg’s funnel plot and Egger’s test based on STATA software v15.1. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were computed to estimate the association. I2-statistic was used to assess heterogeneity. In total, 75 studies comprising 36,125 cases and 31,730 controls were included, and 62 studies were eligible for meta-analysis. A total of 80 captured variants within or near 59 genes were found to be associated with an increased CAD/MI susceptibility. We performed 46 individual meta-analyses tests for 46 variants. The pooled OR of association with CAD/MI ranged from 1.14 to 7.57, with a median (interquartile range) of 1.83 (1.64 – 2.57). With the few studies published so far, there appears to be a unique genetic and clinical susceptibility profile for Arab patients with CAD/MI. The findings of this study will pave the way to perform future genetic association studies that will help identify potential therapeutic targets against CAD/MI.

Keywords


Coronary artery disease, Myocardial infarction, Genetic variations, Genotype-phenotype correlations, Arab countries

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References


Ashley EA, Niebauer J. Coronary artery disease. Cardiology Explained 2004. Remedica.

McPherson R. Genome-wide association studies of cardiovascular disease in European and non-European populations. Current Genetic Medicine Reports. 2014 Mar 1;2(1):1-2.

Verweij N, Eppinga RN, Hagemeijer Y, van der Harst P. Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure. Scientific reports. 2017 Jun 5;7(1):1-9.

Dorn GW, Cresci S. Genome-wide association studies of coronary artery disease and heart failure: where are we going?. Pharmacogenomics. 2009;Oct; 2:213-23.

Wang Y, Wang L, Liu X, Zhang Y, Yu L, Zhang F, Liu L, Cai J, Yang X, Wang X. Genetic variants associated with myocardial infarction and the risk factors in Chinese population. PloS one. 2014 Jan 27;9(1):e86332.

Christiansen MK, Larsen SB, Nyegaard M, Neergaard-Petersen S, Ajjan R, Würtz M, Grove EL, Hvas AM, Jensen HK, Kristensen SD. Coronary artery disease-associated genetic variants and biomarkers of inflammation. PloS one. 2017 Jul 7;12(7):e0180365.

Coronary Artery Disease (C4D) Genetics Consortium. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nature genetics. 2011 Apr;43(4):339.

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature genetics. 2011 Apr;43(4):333-8.

Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K. Large-scale association analysis identifies new risk loci for coronary artery disease. Nature genetics. 2013 Jan;45(1):25-33.

Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K. Large-scale association analysis identifies new risk loci for coronary artery disease. Nature genetics. 2013 Jan;45(1):25-33.

McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007 Jun 8;316(5830):1488-91.

McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007 Jun 8;316(5830):1488-91.

Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH. Genomewide association analysis of coronary artery disease. New England Journal of Medicine. 2007 Aug 2;357(5):443-53.

Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature genetics. 2009 Nov;41(11):1182-90.

Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature genetics. 2009 Mar;41(3):342-7.

Myocardial Infarction Genetics Consortium. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nature genetics. 2009 Mar;41(3):334.

Trégouët DA, König IR, Erdmann J, Munteanu A, Braund PS, Hall AS, Großhennig A, Linsel-Nitschke P, Perret C, DeSuremain M, Meitinger T. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nature genetics. 2009 Mar;41(3):283.

Erdmann J, Großhennig A, Braund PS, König IR, Hengstenberg C, Hall AS, Linsel-Nitschke P, Kathiresan S, Wright B, Trégouët DA, Cambien F. New susceptibility locus for coronary artery disease on chromosome 3q22. 3. Nature genetics. 2009 Mar;41(3):280-2.

Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007 Jun;447(7145):661.

Chan K, Motterle A, Laxton RC, Ye S. Common variant on chromosome 9p21 predicts severity of coronary artery disease. Journal of the American College of Cardiology. 2011 Mar 29;57(13):1497-8.

Sasidhar MV, Reddy S, Naik A, Naik S. Genetics of coronary artery disease–A clinician's perspective. Indian heart journal. 2014 Nov 1;66(6):663-71.

Lloyd-Jones DM, Nam BH, D'Agostino Sr RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. Jama. 2004 May 12;291(18):2204-11.

Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U. Genetic susceptibility to death from coronary heart disease in a study of twins. New England Journal of Medicine. 1994 Apr 14;330(15):1041-6.

Myers RH, Kiely DK, Cupples LA, Kannel WB. Parental history is an independent risk factor for coronary artery disease: the Framingham Study. American heart journal. 1990 Oct 1;120(4):963-9.

Coronary Artery Disease Consortium. Large scale association analysis of novel genetic loci for coronary artery disease. Arteriosclerosis, thrombosis, and vascular biology. 2009 May 1;29(5):774-80.

Roberts R, Stewart AF. Genes and coronary artery disease: where are we?. Journal of the American College of Cardiology. 2012 Oct 30;60(18):1715-21.

O'Donnell CJ, Nabel EG. Genomics of cardiovascular disease. New England Journal of Medicine. 2011 Dec 1;365(22):2098-109.

Subcommittee SS. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016 Jan 26;133(4):e38-60.

Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS medicine. 2006 Nov 28;3(11):e442.

Dai X, Wiernek S, Evans JP, Runge MS. Genetics of coronary artery disease and myocardial infarction. World journal of cardiology. 2016 Jan 26;8(1):1.

Yusuf S, Hawken S, Ôunpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The lancet. 2004 Sep 11;364(9438):937-52.

Okrainec K, Banerjee DK, Eisenberg MJ. Coronary artery disease in the developing world. American heart journal. 2004 Jul 1;148(1):7-15.

Almahmeed W, Arnaout MS, Chettaoui R, Ibrahim M, Kurdi MI, Taher MA, Mancia G. Coronary artery disease in Africa and the Middle East. Therapeutics and clinical risk management. 2012;8:65.

Hajjej A, Almawi WY, Arnaiz-Villena A, Hattab L, Hmida S. The genetic heterogeneity of Arab populations as inferred from HLA genes. PLoS One. 2018 Mar 9;13(3):e0192269.

Ibrāhīm Z. Linguistics in an Age of Globalization: Perspectives on Arabic Language and Teaching. American Univ in Cairo Press; 2008.

Abchee A, Puzantian H, Azar ST, Shbaklo H, Nasrallah A, Sawaya FJ, Alam S, Zalloua PA. Predictors of coronary artery disease in the Lebanese population. Thrombosis research. 2006 Jan 1;117(6):631-7.

Hebbar P, Elkum N, Alkayal F, John SE, Thanaraj TA, Alsmadi O. Genetic risk variants for metabolic traits in Arab populations. Scientific reports. 2017 Jan 20;7(1):1-7.

Jamee Shahwan A, Abed Y, Desormais I, Magne J, Preux PM, Aboyans V, Lacroix P. Epidemiology of coronary artery disease and stroke and associated risk factors in Gaza community–Palestine. PloS one. 2019 Jan 25;14(1):e0211131.

Anand SS, Yusuf S, Vuksan V, Devanesen S, Teo KK, Montague PA, Kelemen L, Yi C, Lonn E, Gerstein H, Hegele RA. Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE). The lancet. 2000 Jul 22;356(9226):279-84.

Al-Nozha MM, Arafah MR, Al-Mazrou YY, Al-Maatouq MA, Khan NB, Khalil MZ, Al-Khadra AH, Al-Marzouki K, Abdullah MA, Al-Harthi SS, Al-Shahid MS. Coronary artery disease in Saudi Arabia. Saudi med J. 2004 Sep 1;25(9):1165-71.

John SE, Antony D, Eaaswarkhanth M, Hebbar P, Channanath AM, Thomas D, Devarajan S, Tuomilehto J, Al-Mulla F, Alsmadi O, Thanaraj TA. Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics. Scientific reports. 2018 Nov 8;8(1):1-30.

Awad AI, Alsaleh FM. 10-year risk estimation for type 2 diabetes mellitus and coronary heart disease in Kuwait: a cross-sectional population-based study. PLoS One. 2015 Jan 28;10(1):e0116742.

Voetsch B, Loscalzo J. Genetic determinants of arterial thrombosis. Arteriosclerosis, thrombosis, and vascular biology. 2004 Feb 1;24(2):216-29.

Watkins H, Farrall M. Genetic susceptibility to coronary artery disease: from promise to progress. Nature Reviews Genetics. 2006 Mar;7(3):163-73.

Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, Danesh J. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66 155 cases and 91 307 controls. The Lancet. 2006 Feb 25;367(9511):651-8.

Ajjan R, Grant PJ. Coagulation and atherothrombotic disease. Atherosclerosis. 2006 Jun 1;186(2):240-59.

Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood, The Journal of the American Society of Hematology. 2000 Mar 1;95(5):1517-32.

Smith A, Patterson C, Yarnell J, Rumley A, Ben-Shlomo Y, Lowe G. Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study. Circulation. 2005 Nov 15;112(20):3080-7.

Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS med. 2009 Jul 21;6(7):e1000097.

Meroufel D, Médiène-Benchekor S, Dumont J, Benhamamouch S, Amouyel P, Brousseau T. Relationship between endothelial nitric oxide synthase gene polymorphisms and the risk of myocardial infarction in the Algerian population. Egyptian Journal of Medical Human Genetics. 2009;10(1).

Kamal HM, Ahmed AS, Fawzy MS, Mohamed FA, Elbaz AA. Thrombin-Activatable Fibrinolysis Inhibitor Thr325Ile Polymorphism as a Risk Factor of Myocardial Infarction in Egyptians. The Egyptian Society Of Cardiology Board Of Directors. 2010 Feb 2:197

Alkhiary W, Abdalaal M, El-Saddik AM. The relation of thrombomodulin G33A and C1418T gene polymorphisms to the risk of acute myocardial infarction in Egyptians. Egyptian Journal of Medical Human Genetics. 2018;19(1):19-22.

Borai IH, Hassan NS, Shaker OG, Ashour E, Badrawy ME, Fawzi OM, Mageed L. Synergistic effect of ACE and AGT genes in coronary artery disease. Beni-Suef University Journal of Basic and Applied Sciences. 2018 Mar 1;7(1):111-7.

Abd El-Aziz TA, Rezk NA. Relation of PAI-1 and TPA genes polymorphisms to acute myocardial infarction and its outcomes in Egyptian patients. Cell biochemistry and biophysics. 2015 Jan 1;71(1):227-34.

Kamal HM, Ahmed AS, Fawzy MS, Mohamed FA, Elbaz AA. Plasma thrombin-activatable fi brinolysis inhibitor levels and Thr325Ile polymorphism as a risk marker of myocardial infarction in Egyptian patients. Acta Cardiologica. 2011 Aug 1;66(4):483-8.

Abd El-Aziz TA, Mohamed RH. Matrix metalloproteinase-9 polymorphism and outcome after acute myocardial infarction. International journal of cardiology. 2017 Jan 15;227:524-8.

Mohamed AA, Rashed L, Amin H, Abu-Farha M, El Fadl SA, Pakhoum S. K469E polymorphism of the intercellular adhesion molecule-1 gene in Egyptians with coronary heart disease. Annals of Saudi medicine. 2010 Nov;30(6):432-6.

Hashad IM, Rahman MF, Alenina N, Bader M, Gad MZ. Investigating the link between MCP-1 A-2518G, RANTES G-403A, CX3CR1 V249I and MTHFR C677T gene polymorphisms and the risk of acute myocardial infarction among Egyptians. Meta Gene. 2017 Feb 1;11:181-8.

Abd El-Aziz TA, Mohamed RH, Hagrass HA. Increased risk of premature coronary artery disease in Egyptians with ABCA1 (R219K), CETP (TaqIB), and LCAT (4886C/T) genes polymorphism. Journal of clinical lipidology. 2014 Jul 1;8(4):381-9.

Sedky NK, Abdel Rahman MF, Hassanein SI, Gad MZ. Genetic variants of CYP2R1 are key regulators of serum vitamin D levels and incidence of myocardial infarction in middle-aged Egyptians. Current pharmaceutical biotechnology. 2018 Mar 1;19(3):265-73.

Settin A, Dowaidar M, El-Baz R, Abd-Al-Samad A, El-Sayed I, Nasr M. Frequency of factor V Leiden mutation in Egyptian cases with myocardial infarction. Hematology. 2008 Jun 1;13(3):170-4.

Elsaid A, Abdel-Aziz AF, Elmougy R, Elwaseef AM. Association of polymorphisms G (–174) C in IL-6 gene and G (–1082) A in IL-10 gene with traditional cardiovascular risk factors in patients with coronary artery disease.

Abdelrauf LM, Rahman MF, Abdel-Maksoud SM, Farag NM, Hashad IM. Association of manganese superoxide dismutase Ala16Val polymorphism in the incidence of acute myocardial infarction in the Egyptians. Journal of Genetic Engineering and Biotechnology. 2017 Dec 1;15(2):415-8.

Shaker OG, Ismail MF. Association of genetic variants of MTHFR, ENPP1, and ADIPOQ with myocardial infarction in Egyptian patients. Cell biochemistry and biophysics. 2014 Jun 1;69(2):265-74.

Sewelam NI, Radwan ER, Andraos AW, Ibrahim BE, Wilson MM. Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients. Egyptian Journal of Medical Human Genetics. 2013 Apr 17;14(2).

Settin A, ElBaz R, Abbas A, Abd-Al-Samad A, Noaman A. Angiotensin-converting enzyme gene insertion/deletion polymorphism in Egyptian patients with myocardial infarction. Journal of the renin-angiotensin-aldosterone system. 2009 Jun;10(2):96-100.

Amir M, Hassanein SI, Rahman MF, Gad MZ. AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians. Molecular biology reports. 2018 Dec 1;45(6):2411-9.

Shendy HA, Hassanein SI, Gad MZ. “Desert” gene (Chr9p21) variants as novel markers for coronary artery disease. Anatolian journal of cardiology. 2017 Aug;18(2):84.

Hussain MK, Almayali AH, Aljabery HA, Kamil ZD. Adeponectin gene polymorphism, rs2241766, is associated with coronary artery disease in Iraqi population. Gene Reports. 2019 Mar 1;14:50-3.

Saade S, Cazier JB, Ghassibe-Sabbagh M, Youhanna S, Badro DA, Kamatani Y, Hager J, Yeretzian JS, El-Khazen G, Haber M, Salloum AK. Large scale association analysis identifies three susceptibility loci for coronary artery disease. PloS one. 2011 Dec 27;6(12):e29427.

Hmimech W, Idrissi HH, Diakite B, Baghdadi D, Korchi F, Habbal R, Nadifi S. Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction. Biomedical reports. 2016 Sep 1;5(3):361-6.

Idrissi HH, Hmimech W, Diakite B, Korchi F, Baghdadi D, Habbal R, Nadifi S. Association of G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms with susceptibility to myocardial infarction in Morocco. Meta Gene. 2016 Sep 1;9:56-61.

Hmimech W, Diakite B, Idrissi HH, Hamzi K, Korchi F, Baghdadi D, Habbal R, Nadifi S. G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco. Biomedical reports. 2016 Nov 1;5(5):618-22.

El-Menyar AA, Rizk NM, Al-Qahtani A, AlKindi F, Elyas A, Farag F, Bakhsh FD, Ebrahim S, Ahmed E, Al-Khinji M, Al-Thani H. The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2015 Apr;20(4):346.

Wakil SM, Ram R, Muiya NP, Mehta M, Andres E, Mazhar N, Baz B, Hagos S, Alshahid M, Meyer BF, Morahan G. A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs. Atherosclerosis. 2016 Feb 1;245:62-70.

Abu-Amero KK, Al-Boudari OM, Mohamed GH, Dzimiri N. E-selectin S128R polymorphism and severe coronary artery disease in Arabs. BMC Medical Genetics. 2006 Dec;7(1):1-5.

Zargar S, Aljafari AA, Wani TA. Variants in MEF2A gene in relation with coronary artery disease in Saudi population. 3 Biotech. 2018 Jul 1;8(7):289.

Hassan MA, Al-Attas OS, Hussain T, Al-Daghri NM, Alokail MS, Mohammed AK, Vinodson B. The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects. Molecular and cellular biochemistry. 2013 Aug 1;380(1-2):121-8.

Cyrus C, Vatte C, Al-Nafie A, Chathoth S, Al-Ali R, Al-Shehri A, Akhtar MS, Almansori M, Al-Muhanna F, Keating B, Al-Ali A. The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians. Human genomics. 2016 Dec;10(1):1-6.

Muiya P, Al-Najai M, Mazher N, Andres E, Alshahid M, Meyer BF, Dzimiri N. The HNF1a is a susceptibility gene for myocardial infarction and dyslipidaemia.

Abu-Amero KK, Al-Boudari OM, Mohamed GH, Dzimiri N. The Glu27 genotypes of the beta2-adrenergic receptor are predictors for severe coronary artery disease. BMC Medical Genetics. 2006 Dec;7(1):1-5.

Muiya PN, ElHawari S, Andres E, Meyer BF, AL-Mohanna F, Alshahid M, Dzimiri NF. The AGT is a susceptibility gene for coronary artery disease.

Al-Hazzani A, Daoud MS, Ataya FS, Fouad D, Al-Jafari AA. Renin–angiotensin system gene polymorphisms among Saudi patients with coronary artery disease. Journal of Biological Research-Thessaloniki. 2014 Dec 1;21(1):8.

AbdulAzeez S, Al-Nafie AN, Al-Shehri A, Borgio JF, Baranova EV, Al-Madan MS, Al-Ali RA, Al-Muhanna F, Al-Ali A, Al-Mansori M, Ibrahim MF. Intronic polymorphisms in the CDKN2B-AS1 gene are strongly associated with the risk of myocardial infarction and coronary artery disease in the Saudi population. International journal of molecular sciences. 2016 Mar;17(3):395.

Dzimiri N, Muiya P, Mohamed G, Alsmadi O, Al-Saud H, Al-Mohanna F, Alshahid M, Meyer B. Haplotypes encompassing the PSMA6 and KIAA0391 Gene Cluster confer risk for Myocardial Infarction.

Angeline T, Isabel W, Tsongalis GJ. Endothelial nitric oxide gene polymorphisms, nitric oxide production and coronary artery disease risk in a South Indian population. Experimental and molecular pathology. 2010 Dec 1;89(3):205-8.

AbdulAzeez S, Al-Nafie AN, Al-Faraidy K, Al-Ali RA, Al-Mansory M, Borgio JF, Al-Muhanna F, Al-Ali AK. Association of SNP rs2487928 on chromosome 10p11. 2 with the risk of coronary artery disease based myocardial infarction in a Saudi population. Int J Clin Exp Pathol. 2016 Jan 1;9(5):5628-34.

Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Hussain T. Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes. Molecular biology reports. 2011 Aug 1;38(6):3703-8.

Elhawari S, Al-Boudari O, Muiya P, Khalak H, Andres E, Al-Shahid M, Al-Dosari M, Meyer BF, Al-Mohanna F, Dzimiri N. A study of the role of the myocyte-specific enhancer factor-2A gene in coronary artery disease. Atherosclerosis. 2010 Mar 1;209(1):152-4.

Muiya NP, Wakil SM, Tahir AI, Hagos S, Najai M, Gueco D, Al-Tassan N, Andres E, Mazher N, Meyer BF, Dzimiri N. A study of the role of GATA4 polymorphism in cardiovascular metabolic disorders. Human genomics. 2013 Dec 1;7(1):25.

Bakhit DM, Muiya P, Gueco D, Meyer BF, Al-Mohanna F, Alshahid M, Dzimiri N. A study of the role of GATA4 gene polymorphism in myocardial infarction.

Wakil SM, Muiya NP, Tahir AI, Al-Najai M, Baz B, Andres E, Mazhar N, Al Tassan N, Alshahid M, Meyer BF, Dzimiri N. A new susceptibility locus for myocardial infarction, hypertension, type 2 diabetes mellitus, and dyslipidemia on chromosome 12q24. Disease markers. 2014 Jun 26;2014.

Kallel A, Sediri Y, Sbaï MH, Mourali MS, Feki M, Elasmi M, Taieb SH, Sanhaji H, Souheil O, Mechmeche R, Jemaa R. The paraoxonase L55M and Q192R gene polymorphisms and myocardial infarction in a Tunisian population. Clinical biochemistry. 2010 Dec 1;43(18):1461-3.

Mehri S, Mahjoub S, Finsterer J, Zaroui A, Mechmeche R, Baudin B, Hammami M. The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population. Journal of the Renin-Angiotensin-Aldosterone System. 2011 Dec;12(4):595-600.

Kallel A, Sebai MH, Sédiri Y, Mourali MS, Elasmi M, Feki M, Haj-Taeib S, Omar S, Sanhaji H, Mechmeche R, Jemaa R. 260 PON1-Q192R gene polymorphism and myocardial infarction in tunisian population. Archives of Cardiovascular Diseases Supplements. 2010 Jan 1;2(1):84.

Kallel A, Sbaï MH, Sediri Y, Abdessalem S, Mourali MS, Feki M, Mechmeche R, Jemaa R, Kaabachi N. Polymorphisms of the NOS3 gene and risk of myocardial infarction in the Tunisian population. Cytokine. 2013 Dec 1;64(3):646-51.

Leban N, Jraba K, Chalghoum A, Hassine S, Elhayek D, Denden S, Lakhdhar R, Maatoug F, Gamra H, Braham H, Chibani JB. Polymorphism of C3 complement in association with myocardial infarction in a sample of central Tunisia. Diagnostic pathology. 2013 Dec 1;8(1):93.

Zidi I, Kharrat N, Abdelhedi R, Hassine AB, Laaribi AB, Yahia HB, Abdelmoula NB, Abid L, Rebai A, Rizzo R. Nonclassical human leukocyte antigen (HLA-G, HLA-E, and HLA-F) in coronary artery disease. Human Immunology. 2016 Apr 1;77(4):325-9.

Souiden Y, Mallouli H, Meskhi S, Chaabouni Y, Rebai A, Chéour F, Mahdouani K. MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity. Biological research. 2016 Dec 1;49(1):22.

Jemaa R, Kallel A, Sediri Y, Feki M, Mourali MS, Abdessalem S. Influence of endothelial nitric oxide synthase gene polymorphisms (894G>T, -786T>C, 4a4b) in Tunisian patients with myocardial infarction. Archives of Cardiovascular Diseases Supplements. 2012; April; 1:93-4.

Hrira MY, Chkioua L, Slimani A, Chahed H, Mosbah H, Khaldoun HB, Ferchichi S, Addad F, Miled A. Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease. Diagnostic pathology. 2012 Dec;7(1):1-5.

Ghazouani L, Abboud N, Mtiraoui N, Zammiti W, Addad F, Amin H, Almawi WY, Mahjoub T. Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease. Journal of thrombosis and thrombolysis. 2009 Feb 1;27(2):191-7.

Sbai MH, Kallel A, Sediri Y, Lassoued M, Mechmeche R, Jemaa R, Kaabachi N. 0184: Genetic association between single nucleotide polymorphisms in the Paraoxonase 1 (PON1) gene and the risk of myocardial infarction in the Tunisian male population. Archives of Cardiovascular Diseases Supplements. 2016 Jan 1;8(1):88.

Ben-Hadj-Khalifa S, Ghazouani L, Abboud N, Ben-Khalfallah A, Annabi F, Addad F, Almawi WY, Mahjoub T. Functional interleukin-10 promoter variants in coronary artery disease patients in Tunisia. European cytokine network. 2010 Jun 1;21(2):136-41.

Abboud N, Ghazouani L, Kaabi B, Ben-Hadj-Khalifa S, Addad F, Marwen M, Almawi WY, Mahjoub T. Evaluation of the contribution of renin angiotensin system polymorphisms to the risk of coronary artery disease among Tunisians. Genetic Testing and Molecular Biomarkers. 2010 Oct 1;14(5):661-6.

Belkahla R, Omezzine A, Kchok K, Rebhi L, Ben IH, Rejeb J, Ben NR, Slimane N, Nabli N, Ben AA, Boughzala E. Effect of polymorphisms on key enzymes in homocysteine metabolism, on plasma homocysteine level and on coronary artery-disease risk in a Tunisian population. InAnnales de cardiologie et d'angeiologie 2008 Aug (Vol. 57, No. 4, pp. 219-224).

Slimani A, Harira Y, Trabelsi I, Jomaa W, Maatouk F, Hamda KB, Slimane MN. Effect of E670G polymorphism in PCSK9 gene on the risk and severity of coronary heart disease and ischemic stroke in a Tunisian cohort. Journal of Molecular Neuroscience. 2014 Jun 1;53(2):150-7.

Ben Ali M, Messaoudi S, Ezzine H, Mahjoub T. Contribution of eNOS variants to the genetic susceptibility of coronary artery disease in a Tunisian population. Genetic Testing and Molecular Biomarkers. 2015 Apr 1;19(4):203-8.

Kallel A, Sediri Y, Abdessalem S, Mourali MS, Feki M, Mechmeche R, Jemaa R, Kaabachi N. 234: Association of the porothrombin 20210GA variant with myocardial infarction in Tunisian population. Archives of Cardiovascular Diseases Supplements. 2013 Jan 1;5(1):78.

Kallel A, Ali SB, Sediri Y, Chabrak S, Elasmi M, Sanhaji H, Souheil O, Haj-Taieb S, Feki M, Mechmeche R, Jemaa R. Association of the insertion/deletion gene polymorphism of the apolipoprotein B signal peptide with myocardial infarction in Tunisian patients. Clinical Chemistry and Laboratory Medicine (CCLM). 2008 Aug 1;46(8):1097-101.

Sediri Y, Kallel A, Ali SB, Omar S, Mourali MS, Elasmi M, Taieb SH, Sanhaji H, Feki M, Mechmeche R, Jemaa R. Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population. Clinical biochemistry. 2010 Jan 1;43(1-2):106-9.

Sediri Y, Kallel A, Mourali MS, Elasmi M, Taïeb SH, Sanhaji H, Feki M, Mechmeche R, Jemaa R, Kaabachi N. 259 Association of rs 2781666 G/T polymorphism of arginase 1 gene with myocardial infarction in the Tunisian population. Archives of Cardiovascular Diseases Supplements. 2011 Jan 1;3(1):85.

Amara A, Mrad M, Sayeh A, Haggui A, Lahideb D, Fekih-Mrissa N, Haouala H, Nsiri B. Association of FV G1691A Polymorphism but not A4070G with coronary artery disease. Clinical and Applied Thrombosis/Hemostasis. 2018 Mar;24(2):330-7.

Sediri Y, Kallel A, Feki M, Mourali S, Elasmi M, Abdessalem S, Mechmeche R, Jemaa R, Kaabachi N. Association of a DNA polymorphism of the apolipoprotein AI–CIII–AIV gene cluster with myocardial infarction in a Tunisian population. European Journal of Internal Medicine. 2011 Aug 1;22(4):407-11.

Jemaa R, Kallel A, Ali SB, Omar S, Chabrak S, Elasmi M, Taieb SH, Sanhaji H, Feki M, Mechmeche R, Kaabachi N. Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with myocardial infarction in Tunisian patients. Clinical Chemistry and Laboratory Medicine (CCLM). 2007 Nov 1;45(11):1476-80.

Jemaa R, Kallel A, Sebai MH, Sediri Y, Feki M, Mechmeche R, Kaabachi N. 0496: Association between the MspI polymorphism of p53 gene and myocardial infraction in the Tunisian male population. Archives of Cardiovascular Diseases Supplements. 2015 Jan 1;7(1):84.

Kallel A, Sbaï MH, Sédiri Y, Feki M, Mourali MS, Mechmeche R, Jemaa R, Kaabachi N. Association between the G20210A polymorphism of prothrombin gene and myocardial infarction in Tunisian population. Biochemical genetics. 2016 Oct 1;54(5):653-64.

Jemaa R, Achouri A, Kallel A, Ali SB, Mourali S, Feki M, Elasmi M, Taieb SH, Sanhaji H, Omar S, Mechmeche R. Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients. Clinical Chemistry and Laboratory Medicine (CCLM). 2008 Oct 1;46(10):1364-8.

Jemaa R, Rojbani H, Kallel A, Ben Ali S, Feki M, Chabrak S, et al. Association between the -2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and myocardial infarction in Tunisian patients. Clinica chimica acta; international journal of clinical chemistry. 2008;390:122-5.

Mehri S, Hammami S, Koubaa N, Nkbi A, Hammami M. Angiotensinogen gene polymorphism associates with acute myocardial infarction risk in Tunisian patients. Archives of Cardiovascular Diseases Supplements. 2012;1(4):10.

Mehri S, Baudin B, Mahjoub S, Zaroui A, Beneteau-Burnat B, Mechmeche R, Hammami M, Arab SB. Angiotensin-converting enzyme insertion/deletion gene polymorphism in a Tunisian healthy and acute myocardial infarction population. Genetic testing and molecular biomarkers. 2010 Feb 1;14(1):85-91.

Youssef SM, Mohamed N, Afef S, Khaldoun BH, Fadoua N, Fadhel NM, Naceur SM. A Pro 12 Ala substitution in the PPARγ2 polymorphism may decrease the number of diseased vessels and the severity of angiographic coronary artery. Coronary artery disease. 2013 Aug 1;24(5):347-51.

Jemaa R, Kallel A, Wafi SB, Sbaï MH, Mechmeche R, Kaabachi N. 0183: A common polymorphism in CD40 Kozak sequence (-1C/T) is associated with myocardial infraction in the Tunisian male population. Archives of Cardiovascular Diseases Supplements. 2016 Jan 1;8(1):87.

Jguirim-Souissi I, Jelassi A, Hrira Y, Najah M, Slimani A, Addad F, Hassine M, Hamda KB, Maatouk F, Rouis M, Slimane MN. 294 T/C polymorphism in the PPAR- delta gene is associated with risk of coronary artery disease in normoiipidemic Tunisians. Genetics and Molecular Research. 2010 Jul 13;9(3):1326-33.

Berger K, Stögbauer F, Stoll M, Wellmann J, Huge A, Cheng S, Kessler C, John U, Assmann G, Ringelstein EB, Funke H. The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case–control studies. Human genetics. 2007 Apr 1;121(2):169-78.

Casas JP, Bautista LE, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation. 2004 Mar 23;109(11):1359-65.

Yoshimura M, Yasue H, Nakayama M, Shimasaki Y, Sumida H, Sugiyama S, Kugiyama K, Ogawa H, Ogawa Y, Saito Y, Miyamoto Y. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Human genetics. 1998 Jul 1;103(1):65-9.

Yan JT, Zhang L, Xu YJ, Wang XJ, Wang CY, Wang DW. Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population. Acta Pharmacologica Sinica. 2011 Nov;32(11):1357-63.

Kobashi G, Yamada H, Ohta K, Kato EH, Ebina Y, Fujimoto S. Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy. American journal of medical genetics. 2001 Oct 15;103(3):241-4.

Jáchymová M, Horký K, Bultas J, Kožich V, Jindra A, Peleška J, Martásek P. Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy. Biochemical and biophysical research communications. 2001 Jun 8;284(2):426-30.

Fattakhov N, Smirnova L, Atochin D, Parshukova D, Skuratovskaia D, Painter Q, Zatolokin P, Semke A, Litvinova L, Ivanova S. Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients. International Journal of Obesity. 2018 Dec;42(12):2036-46.

Akomolafe A, Lunetta KL, Erlich PM, Cupples LA, Baldwin CT, Huyck M, Green RC, Farrer LA, MIRAGE Study Group. Genetic association between endothelial nitric oxide synthase and Alzheimer disease. Clinical genetics. 2006 Jul;70(1):49-56.

Higuchi S, Ohta S, Matsushita S, Matsui T, Yuzuriha T, Urakami K, Arai H. NOS3 polymorphism not associated with Alzheimer's disease in Japanese. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society. 2000 Oct;48(4):685-.

Dahiyat M, Cumming A, Harrington C, Wischik C, Xuereb J, Corrigan F, Breen G, Shaw D, St Clair D. Association between Alzheimer's disease and the NOS3 gene. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society. 1999 Oct;46(4):664-7.

Cai H, Wilcken DE, Wang XL. The Glu-298→ Asp (894G→ T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. Journal of molecular medicine. 1999 Jun 1;77(6):511-4.

Nassar BA, Bevin LD, Johnstone DE, O'Neill BJ, Bata IR, Kirkland SA, Title LM. Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease. American Heart Journal. 2001 Oct 1;142(4):586-9.

Schmoelzer I, Renner W, Paulweber B, Malaimare L, Iglseder B, Schmid P, Schallmoser K, Wascher TC. Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations. European journal of clinical investigation. 2003 Mar;33(3):191-8.

Jaramillo PC, Muñoz A, Lanas C, Lanas F, Salazar LA. Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. Clinica chimica acta. 2006 Sep 1;371(1-2):102-6.

Kim IJ, Bae J, Lim SW, Cha DH, Cho HJ, Kim S, Yang DH, Hwang SG, Oh D, Kim NK. Influence of endothelial nitric oxide synthase gene polymorphisms (− 786T> C, 4a4b, 894G> T) in Korean patients with coronary artery disease. Thrombosis research. 2007 Jan 1;119(5):579-85.

Alp E, Menevse S, Tulmac M, Kan D, Yalcin R, Erkan AF, Cengel A. Lack of association between matrix metalloproteinase-9 and endothelial nitric oxide synthase gene polymorphisms and coronary artery disease in Turkish population. DNA and cell biology. 2009 Jul 1;28(7):343-50.

Broadbent HM, Peden JF, Lorkowski S, Goel A, Ongen H, Green F, Clarke R, Collins R, Franzosi MG, Tognoni G, Seedorf U. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Human molecular genetics. 2008 Mar 15;17(6):806-14.

Szpakowicz A, Kiliszek M, Pepinski W, Waszkiewicz E, Franaszczyk M, Skawronska M, Ploski R, Niemcunowicz-Janica A, Dobrzycki S, Opolski G, Musial WJ. Polymorphism of 9p21. 3 locus is associated with 5-year survival in high-risk patients with myocardial infarction. Plos one. 2014 Aug 8;9(8):e104635.

Björck HM, Länne T, Alehagen U, Persson K, Rundkvist L, Hamsten A, Dahlström U, Eriksson P. Association of genetic variation on chromosome 9p21. 3 and arterial stiffness. Journal of internal medicine. 2009 Mar;265(3):373-81.

Gori F, Specchia C, Pietri S, Crociati L, Barlera S, Franciosi M, Nicolucci A, Signorini S, Brambilla P, Franzosi MG. Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population. BMC medical genetics. 2010 Dec;11(1):1-7.

Qi L, Ma J, Qi Q, Hartiala J, Allayee H, Campos H. Genetic risk score and risk of myocardial infarction in Hispanics. Circulation. 2011 Feb 1;123(4):374-80.

Saade S, Cazier JB, Ghassibe-Sabbagh M, Youhanna S, Badro DA, Kamatani Y, Hager J, Yeretzian JS, El-Khazen G, Haber M, Salloum AK. Large scale association analysis identifies three susceptibility loci for coronary artery disease. PloS one. 2011 Dec 27;6(12):e29427.

Qi L, Li JM, Sun H, Huang XQ, Lin KQ, Chu JY, Yang ZQ. Association between gene polymorphisms and myocardial infarction in Han Chinese of Yunnan province. Zhonghua yi xue yi chuan xue za zhi= Zhonghua yixue yichuanxue zazhi= Chinese journal of medical genetics. 2012 Aug;29(4):413-9.

Gränsbo K, Almgren P, Sjögren M, Smith JG, Engström G, Hedblad B, Melander O. Chromosome 9p21 genetic variation explains 13% of cardiovascular disease incidence but does not improve risk prediction. Journal of internal medicine. 2013 Sep;274(3):233-40.

Lee JY, Lee BS, Shin DJ, Park KW, Shin YA, Kim KJ, Heo L, Lee JY, Kim YK, Kim YJ, Hong CB. A genome-wide association study of a coronary artery disease risk variant. Journal of human genetics. 2013 Mar;58(3):120-6.

Lövkvist H, Sjögren M, Höglund P, Engström G, Jern C, Olsson S, Smith JG, Hedblad B, Andsberg G, Delavaran H, Jood K. Are 25 SNP s from the CARDIoGRAM study associated with ischaemic stroke?. European journal of neurology. 2013 Sep;20(9):1284-91.

Sakalar C, Gurbuz E, Kalay N, Kaya MG. Higher frequency of rs4977574 (the G Allele) on chromosome 9p21. 3 in patients with myocardial infarction as revealed by PCR-RFLP analysis. The Tohoku journal of experimental medicine. 2013;230(3):171-6.

Tragante V, Doevendans PA, Nathoe HM, van der Graaf Y, Spiering W, Algra A, de Borst GJ, de Bakker PI, Asselbergs FW, SMART Study Group. The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk. European heart journal. 2013 Oct 1;34(37):2896-904.

van Setten J, Isgum I, Smolonska J, Ripke S, de Jong PA, Oudkerk M, de Koning H, Lammers JW, Zanen P, Groen HJ, Boezen HM. Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. Atherosclerosis. 2013 Jun 1;228(2):400-5.

Hamrefors V, Hedblad B, Hindy G, Smith JG, Almgren P, Engström G, Sjögren M, Gränsbo K, Orho-Melander M, Melander O. Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21. PloS one. 2014 Jan 22;9(1):e85893.

Huang Y, Ye H, Hong Q, Xu X, Jiang D, Xu L, Dai D, Sun J, Gao X, Duan S. Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis. International journal of molecular sciences. 2014 Oct;15(10):17478-92.

Lee IT, Goodarzi MO, Lee WJ, Rotter JI, Chen YD, Liang KW, Lee WL, Sheu WH. The chromosome 9p21 variant not predicting long-term cardiovascular mortality in Chinese with established coronary artery disease: an eleven-year follow-up study. BioMed Research International. 2014 Jan 1;2014.

Yinko SL, Thanassoulis G, Stark KD, Tsadok MA, Engert JC, Pilote L. Omega-3 fatty acids and the genetic risk of early onset acute coronary syndrome. Nutrition, Metabolism and Cardiovascular Diseases. 2014 Nov 1;24(11):1234-9.

Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. Journal of the American College of Cardiology. 2013 Mar 5;61(9):957-70.

Wang DW, Liu M, Wang P, Zhan X, Liu YQ, Zhao LS. ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease. Genetics and molecular biology. 2015 Dec;38(4):433-43.

Li Y, Yuan H, Sun L, Zhou Q, Yang F, Yang Z, Liu D. β2-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies. Genetic testing and molecular biomarkers. 2019 Feb 1;23(2):124-37.

Reamon-Buettner SM, Cho SH, Borlak J. Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD). BMC Medical Genetics. 2007 Dec 1;8(1):38.

Tomita-Mitchell A, Maslen CL, Morris CD, Garg V, Goldmuntz E. GATA4 sequence variants in patients with congenital heart disease. Journal of medical genetics. 2007 Dec 1;44(12):779-83.

Reamon-Buettner SM, Borlak J. GATA4 zinc finger mutations as a molecular rationale for septation defects of the human heart. Journal of medical genetics. 2005 May 1;42(5):e32-.

Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c. 620C> T mutation in GATA4 is associated with congenital heart disease in South India. BMC medical genetics. 2015 Dec 1;16(1):7.

Reamon-Buettner SM, Cho SH, Borlak J. Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD). BMC Medical Genetics. 2007 Dec 1;8(1):38.

Aoki S, Mukae S, Itoh S, Sato R, Nishio K, Ueda H, Iwata T, Katagiri T. Genetic background in patients with acute myocardial infarction. Japanese heart journal. 2001;42(1):15-28.

Firouzabadi N, Tajik N, Bahramali E, Bakhshandeh H, Maadani M, Shafiei M. Gender specificity of a genetic variant of angiotensin-converting enzyme and risk of coronary artery disease. Molecular biology reports. 2013 Aug 1;40(8):4959-65.

Firouzabadi N, Tajik N, Bahramali E, Bakhshandeh H, Ebrahimi SA, Maadani M, Rasoulian M, Mobasheri T, Shafiei M. Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression. Clinical biochemistry. 2012 Nov 1;45(16-17):1347-52.

Wahlstrand B, Orho-Melander M, Delling L, Kjeldsen S, Narkiewicz K, Almgren P, Hedner T, Melander O. The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension. Journal of hypertension. 2009 Apr 1;27(4):769-73.

Akinyemi R, Arnett DK, Tiwari HK, Ovbiagele B, Sarfo F, Srinivasasainagendra V, Irvin MR, Adeoye A, Perry RT, Akpalu A, Jenkins C. Interleukin–6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous West African Men. Journal of the neurological sciences. 2017 Aug 15;379:229-35.

Smith JG, Melander O, Lövkvist H, Hedblad B, Engström G, Nilsson P, Carlson J, Berglund G, Norrving B, Lindgren A. Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study. Circulation: Cardiovascular Genetics. 2009 Apr;2(2):159-64.

Newton-Cheh C, Cook NR, VanDenburgh M, Rimm EB, Ridker PM, Albert CM. Common variants at 9p21 are associated with sudden and arrhythmic cardiac death. Circulation. 2009 Nov 24;120(21):2062.

Lahtinen AM, Noseworthy PA, Havulinna AS, Jula A, Karhunen PJ, Kettunen J, Perola M, Kontula K, Newton-Cheh C, Salomaa V. Common genetic variants associated with sudden cardiac death: the FinSCDgen study. PloS one. 2012 Jul 23;7(7):e41675.

Aspelund T, Grübler MR, Smith AV, Gudmundsson EF, Keppel M, Cotch MF, Harris TB, Jorde R, Grimnes G, Joakimsen R, Schirmer H. Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts. Nutrients. 2019 Jan;11(1):74.

Ramos‐Lopez E, Brück P, Jansen T, Herwig J, Badenhoop K. CYP2R1 (vitamin D 25‐hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes/metabolism research and reviews. 2007 Nov;23(8):631-6.

Zhang Y, Wang X, Liu Y, Qu H, Qu S, Wang W, Ren L. The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children. Swiss medical weekly. 2012 Jul 16;142(2930).

Elkum N, Alkayal F, Noronha F, Ali MM, Melhem M, Al-Arouj M, Bennakhi A, Behbehani K, Alsmadi O, Abubaker J. Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes. PloS one. 2014 Nov 18;9(11):e113102.

Rai H, Parveen F, Kumar S, Kapoor A, Sinha N. Association of endothelial nitric oxide synthase gene polymorphisms with coronary artery disease: an updated meta-analysis and systematic review. PLoS One. 2014 Nov 19;9(11):e113363.

Shahid SU, Shabana, Rehman A. Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with blood pressure and serum lipid levels in subjects with coronary artery disease from pakistan. Annals of human genetics. 2017 Jul;81(4):129-34.

Szalai C, Duba J, Prohászka Z, Kalina Á, Szabó T, Nagy B, Horváth L, Császár A. Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp (a) and MCP-1− 2518 G/G genotype in CAD patients. Atherosclerosis. 2001 Sep 1;158(1):233-9.

Alonso-Villaverde C, Coll B, Parra S, Montero M, Calvo N, Tous M, Joven J, Masana L. Atherosclerosis in patients infected with HIV is influenced by a mutant monocyte chemoattractant protein-1 allele. Circulation. 2004 Oct 12;110(15):2204-9.

Lin HL, Ueng KC, Hsieh YS, Chiang WL, Yang SF, Chu SC. Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility. Molecular biology reports. 2012 Sep 1;39(9):9023-30.

Kaur R, Matharoo K, Arora P, Bhanwer AJ. Association of− 2518A> G promoter polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with type 2 diabetes and coronary artery disease. Genetic testing and molecular biomarkers. 2013 Oct 1;17(10):750-5.

Zhang X, Han Y, Kang J, Yan C. A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population. Clinica Chimica Acta. 2009 May 1;403(1-2):241-3.

van Wijk R, Nieuwenhuis K, van den Berg M, Huizinga EG, van der Meijden BB, Kraaijenhagen RJ, van Solinge WW. Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency. Blood, The Journal of the American Society of Hematology. 2001 Jul 15;98(2):358-67.

Hamzi K, Diakité B, Hmimech W, Nadifi S. First study of the C2491t nonsense mutation frequency in moroccan healthy population. Journal of Molecular Neuroscience. 2013 Oct 1;51(2):425-7.

Diakite B, Hamzi K, Hmimech W, Nadifi S. First study of C2491T FV mutation with ischaemic stroke risk in Morocco. Journal of genetics. 2015 Jun 1;94(2):313-5.

Ercan B, Tamer L, Sucu N, Pekdemir H, Çamsarı A, Atik U. Factor VLeiden and prothrombin G20210A gene polymorphisms in patients with coronary artery disease. Yonsei medical journal. 2008 Apr 30;49(2):237-43.

Slama DB, Fekih-Mrissa N, Haggui A, Nsiri B, Baraket N, Haouala H, Gritli N. Lack of association between factor V Leiden and prothrombin G20210A polymorphisms in Tunisian subjects with a history of myocardial infarction. Cardiovascular Pathology. 2013 Jan 1;22(1):39-41.

Jin B, Li Y, Ge-Shang QZ, Ni HC, Shi HM, Shen W. Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: evidence from 15,041 cases and 21,507 controls. Molecular biology reports. 2011 Apr 1;38(4):2371-6.

Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. International journal of cardiology. 2013 Sep 30;168(2):934-45.

Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S, Murphy A. Growing epidemic of coronary heart disease in low-and middle-income countries. Current problems in cardiology. 2010 Feb 1;35(2):72-115.

Zayed H. The Qatar genome project: translation of whole‐genome sequencing into clinical practice. International Journal of Clinical Practice. 2016 Oct;70(10):832-4.

Zayed H. The Arab genome: health and wealth. Gene. 2016 Nov 5;592(2):239-43.

Zayed H, Ouhtit A. Accredited genetic testing in the Arab Gulf region: reinventing the wheel. Journal of human genetics. 2016 Jul;61(7):673-4.

Ben Ali M, Messaoudi S, Ezzine H, Mahjoub T. Contribution of eNOS variants to the genetic susceptibility of coronary artery disease in a Tunisian population. Genetic Testing and Molecular Biomarkers. 2015 Apr 1;19(4):203-8.




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